Modulation of Transmural Repolarization
نویسندگان
چکیده
منابع مشابه
Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity.
AIMS To elucidate the properties of the PMJ and myocardium underlying these effects. Transmural heterogeneity of action potential duration (APD) is known to play an important role in arrhythmogenesis. Regions of non-uniformities of APD gradients often overlap considerably with the location of Purkinje-muscle junctions (PMJs). We therefore hypothesized that such junctions are novel sources of lo...
متن کاملAmiodarone reduces transmural heterogeneity of repolarization in the human heart.
OBJECTIVES The present work was designed to test the effects of amiodarone therapy on action potential characteristics of the three cell types observed in human left ventricular preparations. BACKGROUND The electrophysiologic basis for amiodarone's exceptional antiarrhythmic efficacy and low proarrhythmic profile remains unclear. METHODS We used standard microelectrode techniques to investi...
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See article by Taggart et al. [50] (pages 454-462) in or endocardium in response to a slowing of rate and/or in this issue. response to agents that normally prolong the action potential [3]. These features of the M cell are due at least Studies conducted over the past dozen years or so have in part to the presence of a smaller slowly activating demonstrated that ventricular myocardium is not ho...
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To the editor We read the article written by Nuis, et al. The authors investigated the effects of transcatheter aortic valve implantation (TAVI) on corrected QT dispersion (cQTD) in severe aortic stenosis patients. They concluded that, 40% of patients had defective cQTD recovery at six months after the procedure and this was associated with increased late mortality risk. We would like to cont...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2005
ISSN: 0077-8923
DOI: 10.1196/annals.1341.028